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Hokie360

Joined: 08/26/2006 Posts: 17911
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Here's the press release for Pfizer/BioNTech.


US results were release a week or two ago, and discussed here. This is the German Phase 1/2 study, with 60 participants. In addition to similar antibody results as the US study, this study also showed strong T-cell responses.

From the link:
The data further demonstrated the ability of BNT162b1 to elicit high SARS-CoV-2 neutralizing titers

BNT162b1 elicited strong CD4+ and CD8+ T cell responses against SARS-CoV-2- receptor binding domain (RBD), compared to baseline

The RBD-specific, interferon-g+, IL-2+, CD8+ T cells elicited by BNT162b1 in immunized participants indicate a strong potential for cell mediated anti-viral activity

T cell cytokine profile shows vaccine elicited T cells exhibit a Th1 phenotype, which is associated with antiviral properties

BNT162b1 induced antibodies had broadly neutralizing activity in pseudovirus neutralization assays across a panel of sixteen SARS-CoV-2 RBD variants identified in published SARS-CoV-2 sequences and against the newly dominant D614G strain

Robust specific antibody and T cell responses, (both of which are considered by experts as key to a vaccine ensuring protection against disease) elicited by the BNT162b1 mRNA vaccine against RBD suggest a potential for multiple beneficial protective mechanisms against COVID-19

Local reactions and systemic events after immunization with BNT162b1 were dose-dependent, generally mild to moderate and transient, with occasional severe adverse events (Grade 3, e.g. flu-like symptoms and injection site reactions) that resolved spontaneously or could be managed with simple measures - no serious adverse events were reported

(In response to this post by VTSnake)

Link: Pfizer and BioNTech Announce Early Positive Update from German Phase 1/2 COVID-1


Posted: 07/20/2020 at 2:36PM



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